BIOMAPS

Bio-Inorganic and Organic Molecular And Peptidic Scaffolds for probing amyloid related biological issues

Our project lies in the wide biological context of pathologic and physiologic amyloid related health issues. Amyloids are ubiquitous structures in Nature. They are involved in several pathologies, such as neurodegenerative diseases (Alzheimer, Parkinson…), diabetes and in HIV infection enhancement and fertility issues as it has been recently evidenced.

A common feature in these diseases is the concomitant presence of a large pool of loosely bound Zn and Cu ions with the amyloidogenic peptide of interest. In the present project, three peptides that represent the various amyloid related health issues will be under focus: Amyloid-β (neurodegenerative disease), Amylin (type-2 Diabetes Mellitus, non-neurodegenerative disease) and SEM (physiological role).

 

In this context we aim at designing, synthetizing and probing in biological environments new multi-functional optical tools based on molecular and peptide scaffolds for: (i) the molecular understanding of amyloids formation, their specific recognition and imaging ; (ii) the metal ions shuttling through neuronal membranes and its impact in amyloid detoxification.

 

Research by the BIOMAPS team aims at acquiring new fundamental data about the forming mode of amyloid structures as well as about their involvement in various physiological and pathological processes. To these ends our project relies on the design of new “smart” markers of various amyloids. The outlook of these works relate to diagnostic and therapeutic applications with respect to pathological dysfunctions with high prevalences in Public Health.

Team leaders

Béatrice Mestre-Voegtlé
Béatrice Mestre-Voegtlé
Christelle Hureau-Sabater
Christelle Hureau-Sabater

Partner Labs

LCC-300x230
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Key points

Selected publications
  • Faller, P., Hureau, C. and La Penna, G.: Metal ions and intrinsically disordered proteins and peptides : froms Cu/Zn amyloid-ß to general principles. Acc. Chem. Res., 2014, 47, 2252-2259.
  • Noël, S., Cadet, S., Gras, E. and Hureau, C. : The benzazole scaffold: a SWAT to combat Alzheimer’s disease. Chem. Soc. Rev., 2013, 42, 7747-7762.
  • Faller, P., Hureau, C. and Berthoumieu, O.: Role of metal ions in the sel-assembly of the Alzheimer’s amyloid-ß peptide. Inorg. Chem., 2013, 52, 12193-12206.
  • Aliés, B., Hureau, C. and Faller, P. :The role of metal ions in amyloid formation : general principles from model peptides. Metallomics, 2013, 5, 183-192.
  • Hureau, C. :Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-ß peptides involved in Alzheimer disease. Coord. Chem. Rev., 2012, 256, 2164-2174.
Team members
  • Christelle Hureau (CR CNRS),
  • Béatrice Mestre-Voegtlé (MCU),
  • Emmanuel Gras (CR CNRS),
  • Philippe Valet (Pr),
  • Jean-Philippe Pradère (CR INSERM),
  • Safouane Hamdi (MCU PH).
Collaborations
  • Team SoMO, Stefan Chassaing, ITAV,
  • Team hNM3D, Sophie Pautot, ITAV,
  • Team Biométaux et Chimie Biologique, Peter Faller, Institut de Chimie de Strasbourg,
  • Team REMEMBeR, Laure Verret, CRCA Toulouse.

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Contact

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+33 5 82 99 10 42