ANUBIS

Exploring new methods for cell death detection

There exist many methods to detect and quantify cell death. Most are based on the recognition of biochemical alterations of the cell or of the nucleus, activation of transduction signals or simply by the examination of the cell structure. However, these methods are expensive, time consuming, more or less sensitive and are often not suitable for very small quantities of biological material.

Our project aims to develop cost effective, fast, efficient and highly sensitive methods for detecting cell death.

 

 

EXPECTED OUTCOMES

Propose a new commercial method for the detection of cell death

Chefs d'équipe

C.Touriol, E.Lacazette & H.Laurell

Laboratoires partenaires

Autres informations

Selection de références
  • Basset, C., Bonnet-Magnaval, F., Navarro, M.G., Touriol, C., Courtade, M., Prats, H., Garmy-Susini, B. and Lacazette, E. Api5 a new cofactor of estrogen receptor alpha involved in breast cancer outcome. Oncotarget, (2017) 8, 52511-52526.
  • Bonnet-Magnaval, F., Philippe, C., Van Den Berghe, L., Prats, H., Touriol, C. and Lacazette, E. Hypoxia and ER stress promote Staufen1 expression through an alternative translation mechanism. Biochemical and biophysical research communications, (2016) 479, 365-371.
  • Chantalat E, Boudou F, Laurell H, et al. The AF-1-deficient estrogen receptor ERα46 isoform is frequently expressed in human breast tumors. Breast Cancer Res., (2016) Dec 7;18(1):123
  • Philippe C, Dubrac A, Quelen C, Desquesnes A, Van Den Berghe L, Ségura C, Filleron T, Pyronnet S, Prats H, Brousset P, Touriol C. PERK mediates the IRES-dependent translational activation of mRNAs encoding angiogenic growth factors after ischemic stress. Science Signaling, (2016) May 3;9(426):ra44.
  • Vaysse C, Philippe C, Martineau Y, Quelen C, Hieblot C, Renaud C, Nicaise Y, Desquesnes A, Pannese M, Filleron T, Escourrou G, Lawson M, Rintoul RC, Delisle MB, Pyronnet S, Brousset P, Prats H, Touriol C. Key contribution of eIF4H-mediated translational control in tumor promotion. Oncotarget, (2015) Nov 24;6(37):39924-40.
Membres de l'équipe
  • Amandine Baillet (IR)
  • Eric Lacazette (MCU –University Paul Sabatier)
  • Henrik Laurell (CR – INSERM)
  • Christian Touriol (CR – INSERM)
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Collaborations
  • Toulouse Tech Transfer
  • IUCT Oncopole

Nos soutiens

  • Université de ToulouseUniversité de Toulouse
  • Toulouse Tech TransferToulouse Tech Transfer

Contact

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+33 5 82 99 10 36