7/12 : C.Roux – Upconverting nanoparticles for bioimaging 🗓 🗺
Upconverting nanoparticles: from design and synthesis to application in bioimaging
In many research contexts, luminescent nanoparticles have surpassed soluble fluorophores, thanks to key advantages such as resistance to photobleaching, longer excited state lifetimes, large Stokes shift. Whereas quantum dots have been in the spotlights for two decades, another class of nano-objects is currently coming of age: Upconverting nanoparticles (UCNPs).
These particles, doped with lanthanide ions operate in a radically different, anti-Stokes fluorescence mode, where accumulation of photons on extremely long-lived excited states results in emissions at shorter wavelengths than the excitation. UCNPs enjoy quasi-null bleaching and blinking, are advantageously excited in the biological imaging window (near infrared), and provide sharp emission bands ranging from UV to NIR. In this presentation, we will give an overview of upconversion as a concept and the state of the art in UCNP-based imaging. We will then detail some of our contributions to the field, ranging from improved synthetic protocols based on microwave heating, to application in in vivo bioimaging.
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