AMOTIS

Advanced molecular tools for imaging and sustainability

The AMoTIS Team focus on developing new chemical syntheses and new processes to access, in a sustainable fashion, complex molecular structures.

 

These topics, we are interested in, include:

 

  1. the generation of molecular diversity and complexity from simple precursors under safe and environmentally friendly conditions with a strong contribution of main group elements (especially Boron), including catalytic processes;
  2. a specific focus on the introduction of fluorine atom onto molecules of biological relevance either through C–F or B–F bond formation;
  3. the combination of the first two topics to provide new accesses to radiofluorinated probes for Positron Emission Tomography (PET) imaging and multimodal probes.

 

Thus innovative chemical methods are pursued based on the expertise of the group members from main group chemistry, organic synthesis and catalysis to radiopharmaceutical production and in vivo injection. Close collaborations with imaging centres are opening the downstream developments of the projects taking off from the chemical bench and aiming at a bedside landing.

 


From chemistry to imaging

AMOTIS slide

Team leader

Emmanuel GRAS
Emmanuel GRAS

Partner Labs

LCC
LHFA
TONIC

Key points

Selected references
  • Expanding the Balz-Schiemann Reaction: organotrifluoroborates serve as competent sources of fluoride ion for fluoro-dediazoniation» Mohy El Dine, T.; Sadek, O.; Gras, E.; Perrin, D.M. Chem. Eur. J. 2018, 24, 14933-14937.
  • Selective mono N-methylation of anilines with methanol catalyzed by rhenium complexes: an experimental and theoretical study » Duo Wei, D.; Sadek, O.; Dorcet, V.; Roisnel, T.; Darcel, C.; Gras, E.; Clot, E.; Sortais, J.-B. Catal. 2018, 366, 300-309.
  • Expedited route to fully substituted amino-pyrazole building blocks and their further transformations » Kuleshova, O., Khilya, O., Volovenko, Y., Mallet-Ladeira, S., Dyakonenko, V., Gras, E. ACS Omega, 2017, 2, 8911-8927.
  • The forgotten nitro-aromatic phosphines as weakly donating P- ligands: a N-aryl-benzimidazolyl series in RhCl(CO) complexes » Zhu, C., Gras, E., Duhayon, C., Lacassin, F., Cui, X., Chauvin, R. Asian J., 2017, 12, 2845-2856.
  • [18F]-Fluoride Capture and Release: azeotropic drying free nucleophilic aromatic radiofluorination assisted by a Phosphonium Borane.”, Perrio, C., Schmitt, S., Pla, D., Gabbaï, F., Chansaenpak, K., Mestre-Voegtle, B., Gras, E. Commun., 2017, 53, 340-343.
  • Metal-free intermolecular azide-alkyne cycloaddition promoted by glycerol”, Rodriguez-Rodriguez, M., Gras, E., Pericas, M.A., Gomez, M. Eur. J., 2015, 21, 18706-18710.“Naphthylaminoborane: From structural switches to frustrated Lewis pairs reactivity”, Pla, D. Sadek, O., Cadet, S., Mestre-Voegtlé, B., Gras, E. Dalton Trans. 2015, 44, 18340-18346.
Team members
  • Emmanuel Gras (CNRS- LCC)
  • Montserrat Gomez (PU – LHFA)
  • Daniel Pla (CNRS – LHFA)
  • Anne Sophie Salabert (AHU – ToNIC)
  • Marie Baurain (PhD – ToNIC)
  • Thais Nogueira (Post-Doc – ITAV)
  • Justine Beuscart (M2 – ITAV)
  • Nicolas Jean Bart (M2 – ITAV)
  • Louis Cambeilh (M2 – ITAV)
Collaborations
  • CRCT (Toulouse – Dr P. Cordelier)
  • I2MC (Toulouse – Drs M. Laffargue & O. Lairez)
  • Stromalab (Toulouse – Dr A.Carrière-Pazat)
  • LISBP (INSA Toulouse – Pr M. Remaud-Simeon, Drs I. André & G. Lippens)
  • University of British Columbia (Vancouver, Canada – Pr D. Perrin)
  • Texas A&M University (College Station, USA – Pr F. Gabbaï)
  • Crump Institute for Molecular Imaging (UCLA, USA – Pr M. van Dam)
  • Taras Shevchenko National University (Kiev, Ukraine – Pr Y. Volovenko)

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Contact

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+33 5 82 99 10 15