Our project lies in the wide biological context of pathologic and physiologic amyloid related health issues. Amyloids are ubiquitous structures in Nature. They are involved in several pathologies, such as neurodegenerative diseases (Alzheimer, Parkinson…), diabetes and in HIV infection enhancement and fertility issues as it has been recently evidenced.
A common feature in these diseases is the concomitant presence of a large pool of loosely bound Zn and Cu ions with the amyloidogenic peptide of interest. In the present project, three peptides that represent the various amyloid related health issues will be under focus: Amyloid-β (neurodegenerative disease), Amylin (type-2 Diabetes Mellitus, non-neurodegenerative disease) and SEM (physiological role).
In this context we aim at designing, synthetizing and probing in biological environments new multi-functional optical tools based on molecular and peptide scaffolds for: (i) the molecular understanding of amyloids formation, their specific recognition and imaging ; (ii) the metal ions shuttling through neuronal membranes and its impact in amyloid detoxification.
Research by the BIOMAPS team aims at acquiring new fundamental data about the forming mode of amyloid structures as well as about their involvement in various physiological and pathological processes. To these ends our project relies on the design of new “smart” markers of various amyloids. The outlook of these works relate to diagnostic and therapeutic applications with respect to pathological dysfunctions with high prevalences in Public Health.